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This Patient Information has been approved by the U. Adding plans allows you to compare formulary status to other drugs in the same class. Phenytoin In 12 normal-weight subjects receiving XENICAL 120 mg three times a day for 7 days, XENICAL did not alter the pharmacokinetics of a single 300-mg dose of phenytoin.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. You may report side effects to FDA at 1-800-FDA-1088 or at www. Losing weight may mean you need adjustments to these medications. Postmarketing Experience The following adverse reactions have been identified during postapproval use of XENICAL.
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Do not double a dose to make up for one you have missed. Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body. These medicines work by targeting the absorption of dietary fat in your body rather than suppressing your appetite.
12 to 18 without the advice of a doctor. Your pharmacist may be able to advise you on managing side effects. Financial terms of the agreement were not disclosed. Archived from the original on 29 December 2007. This medication can make it harder for your body to absorb fat-soluble vitamins, such as vitamins A, D, E, and K. Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body.
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Patients should not take XENICAL if they are pregnant, have chronic malabsorption syndrome, cholestasis or hypersensitivity to XENICAL or to any component of this product . BMI is not a direct measure of fat and these guidelines do not apply to athletes and pregnant women. Following one year of treatment, BMI decreased by an average of 0. Cholelithiasis Substantial weight loss can increase the risk of cholelithiasis.
Accident and Emergency at your nearest hospital if you think that you or anyone else may have taken too much XENICAL, even if there are no signs of discomfort or poisoning. Tell your pharmacist or doctor if you are taking any other medicines including any that you have bought from a pharmacy, supermarket or healthfood shop. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Four-year Results : Long-term Weight Control And Risk Factors In the 4-year double-blind, placebo-controlled XENDOS study, the effects of XENICAL in delaying the onset of type 2 diabetes and on body weight were compared to placebo in 3304 obese patients who had either normal or impaired glucose tolerance at baseline. This information does not take the place of talking to your doctor about your medical condition or your treatment.
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Orlistat and its M1 and M3 metabolites were also subject to biliary excretion. You can ask your pharmacist or doctor for information about XENICAL that is written for health professionals. Related Links List Xenical side effects by likelihood and severity.
What Did Gastroenterologists Learn in the Past 12 Months That PCPs Should Know? SIDE EFFECTS Clinical Trials Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in patients. GSK’s sales force, one of the strongest in the industry, to be competitive in a challenging market.
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XENICAL and cyclosporine should not be simultaneously coadministered. Use with caution if benefits outweigh risks. Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent”.
Alli became available in the U. If you take a cyclosporine medicine, take XENICAL and cyclosporine at least 3 hours apart. Do not give XENICAL to children or adolescents under 18 years of age.
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Do not give this medication to anyone else, even if they have the same symptoms as you do. In addition, all patients were offered nutritional counseling. You may report side effects to FDA at 1-800-FDA-1088. The following side effects occur commonly with the use of orlistat.
Orlistat should be used only by the person for whom it was prescribed. To view formulary information first create a list of plans. These vitamins are important if you are nursing a baby.
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After 1 year of treatment, 45. Do not take XENICAL if you are pregnant or plan to become pregnant. Your doctor will tell you how much XENICAL to take and when to take it. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48 to 72 hours. If this occurs, contact your doctor as soon as possible. You may report side effects to FDA at 1-800-FDA-1088.
During the study, all patients were instructed to take a multivitamin containing fat-soluble vitamins at least 2 hours before or after ingestion of XENICAL. The contents herein are for informational purposes only. XENICAL may affect the way other medicines work, and other medicines may affect the way XENICAL works.
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Contact the applicable plan provider for the most current information. Call your doctor for medical advice about side effects. Clinical Studies The long-term effects of XENICAL on morbidity and mortality associated with obesity have not been established.
The above information is provided for general informational and educational purposes only. You should not breast-feed while taking XENICAL. Patients should be advised to adhere to dietary guidelines . Patients should also be advised to take multivitamin supplementation at least two hours before or after the administration of XENICAL, or at bedtime . Nursing Mothers It is not known if XENICAL is present in human milk.
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Do not start a new medication without telling your doctor. If you notice other effects not listed above, contact your doctor or pharmacist. Tell your doctor if your condition does not improve or if it worsens.
Most commonly, these are “non-preferred” brand drugs or specialty prescription products. Kidney stones: If you have a history of kidney stones, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Study 14 161 was conducted with primary care physicians. If you are already on a multivitamin, take it at least 2 hours before or after taking orlistat, or take it at bedtime. Most commonly, these are generic drugs.
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Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. When taken with a meal, XENICAL interferes with the activity of these enzymes. For XENICAL, the most common adverse events resulting in discontinuation of treatment were gastrointestinal. Be careful not to replace the fat in your diet with large quantities of other foods, such as sugar and alcohol.
Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial”. Take your vitamin or supplement at bedtime, or at least 2 hours before or after you take orlistat. Your list will be saved and can be edited at any time.