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Call your doctor for medical advice about side effects. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. XENICAL-treated patients and increased by an average of 0. The inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides.
Take XENICAL with your meals or up to one hour after your meal. Study 14 161 was conducted with primary care physicians. Concomitant Medications Patients should be asked if they are taking cyclosporine, beta carotene or vitamin E supplements, levothyroxine, warfarin, antiepileptic drugs, amiodarone, or antiretroviral drugs due to potential interactions .
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Caution should be exercised when XENICAL is administered to a nursing woman. Do not increase your dose or use this drug more often or for longer than prescribed. If you miss a meal or have a meal without fat, you can skip your dose of XENICAL. Pediatric Patients In clinical trials with XENICAL in adolescent patients ages 12 to 16 years, the profile of adverse reactions was generally similar to that observed in adults. Postmarketing Experience The following adverse reactions have been identified during postapproval use of XENICAL. For patients receiving both XENICAL and cyclosporine therapy, administer cyclosporine 3 hours after XENICAL.
Are You at Risk for Dementia? Levothyroxine Hypothyroidism has been reported in patients treated concomitantly with XENICAL and levothyroxine postmarketing. Orlistat should be given with caution to patients with a history of hyperoxaluria or calcium oxalate nephrolithiasis. Patients should not take XENICAL if they are pregnant, have chronic malabsorption syndrome, cholestasis or hypersensitivity to XENICAL or to any component of this product .
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Orlistat is a white to off-white crystalline powder. The diet utilized during year 1 was a reduced-calorie diet. Cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure have been reported. Weight-loss may affect glycemic control in patients with diabetes mellitus. Trending price is based on prices over last 90 days.
Orlistat 120mg is used in the treatment of obesity. 24,000 prescription drugs, over-the-counter medicines and natural products. If a meal is missed or contains no fat, the dose of orlistat should be omitted. This Patient Information leaflet summarizes the most important information about XENICAL.
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The iron balance was decreased by 64. If you take cyclosporine, take it at least 3 hours before or after orlistat to make sure the full dose of cyclosporine is absorbed into your bloodstream. Related Links What should I know regarding pregnancy, nursing and administering Orlistat Capsule to children or the elderly? XENICAL should not be used after the given expiration date. Take a multivitamin containing vitamins A, D, E, K, and beta-carotene one time each day. Nursing Mothers It is not known if XENICAL is present in human milk.
Discontinuation Of Treatment In controlled clinical trials, 8. What are the ingredients in XENICAL? Following one year of treatment, BMI decreased by an average of 0. Orlistat is a reversible inhibitor of lipases. All studies, with the exception of 14 161, were conducted at centers specialized in treating obesity and complications of obesity. These are not all the possible side effects of XENICAL.
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General information about the safe and effective use of XENICAL. Alli 120 CT Orlistat Weight Loss Capsules Factory Sealed Bottle NEW Exp. Talk to your doctor right away if your seizures happen more often or get worse while you take XENICAL. Bedtime is a good time to take your multivitamin. If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects.
Buying drugs in your country requires a prescription. INDICATIONS XENICAL is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Alli Orlistat 60 mg Weight Loss Aid 120 Capsules. Dosing Instructions Patients should be counseled to take XENICAL as directed with meals or up to one hour after a meal. Amiodarone A pharmacokinetic study, where amiodarone was orally administered during orlistat treatment, demonstrated a reduction in exposure to amiodarone and its metabolite, desethylamiodarone .
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In addition, all patients were placed on a behavior modification program and offered exercise counseling. There have been reports of hepatic failure observed with the use of XENICAL in postmarketing surveillance, with some of these cases resulting in liver transplant or death . You may report side effects to Health Canada at 1-866-234-2345. Keep XENICAL in a tightly closed container.
Over weight adults 18 years of age and older: 60 mg 3 times daily with each meal containing fat. 0 out of 5 stars – Alli Orlistat 60 mg Weight Loss Aid 120 Capsules. Pharmacokinetics Absorption Systemic exposure to orlistat is minimal. Inactive Ingredients : microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, talc, gelatin and titanium dioxide.
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They may not work as well while you take XENICAL. For XENICAL, the most common adverse events resulting in discontinuation of treatment were gastrointestinal. Rare cases of hypersensitivity have been reported with the use of XENICAL.
However, GI adverse events may occur in some individuals over a period of 6 months or longer. If you notice other effects not listed above, contact your doctor or pharmacist. Safely throw away medicine that is out of date or no longer needed.
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Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and betacarotene, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition . DRUG INTERACTIONS Cyclosporine Data from a XENICAL and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when XENICAL was coadministered with cyclosporine. Acute oxalate nephropathy after treatment with XENICAL has been reported in patients with or at risk for renal disease . Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.
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What are the possible risks of XENICAL? Oily discharge may be clear or have a coloration such as orange or brown. Its empirical formula is C29H53NO5, and its molecular weight is 495. See “What should I tell my doctor before taking XENICAL? Rare cases of leukocytoclastic vasculitis have been reported.
GI adverse events associated with XENICAL treatment lasted for less than 1 week, and a majority lasted for no more than 4 weeks. It may be necessary to discontinue treatment. Do not take XENICAL if you are pregnant or plan to become pregnant. If you take a levothyroxine medicine, take XENICAL and levothyroxine at least 4 hours apart.
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XENICAL patients had a normal oral glucose tolerance test while 10. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to XENICAL exposure. The vitamin supplement should be taken at least 2 hours before or after the administration of XENICAL, such as at bedtime.
Onset of Type 2 Diabetes in Obese Patients In the XENDOS trial, in the overall population, XENICAL delayed the onset of type 2 diabetes such that at the end of four years of treatment the cumulative incidence rate of diabetes was 8. During the study, all patients were instructed to take a multivitamin containing fat-soluble vitamins at least 2 hours before or after ingestion of XENICAL. Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene . In the 4-year XENDOS study, the general pattern of adverse events was similar to that reported for the 1- and 2-year studies with the total incidence of gastrointestinal-related adverse events occurring in year 1 decreasing each year over the 4-year period. Table 4 illustrates the percentage of adult patients on XENICAL and placebo who developed a low vitamin level on two or more consecutive visits during 1 and 2 years of therapy in studies in which patients were not previously receiving vitamin supplementation.