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Ornithine acts as a catalyst in the process of urea formation. This section needs more medical references for verification or relies too heavily on primary sources. Acetyl co A, in excess inhibits PDH complex, but it has no effect on activity of Isocitrate dehydrogenase.
Prior to a race, many marathon runners will try to increase their glycogen concentrations by loading up with foods with a high starch content, such as pasta. Out of all the mentioned enzymes , Glutamate decarboxylase is the only enzyme which is B6 dependent, hence GABA formation would be the only process affected by B6 deficiency.
The sirolimus is formulated in a polymer coating that affords controlled release through the healing period following coronary intervention. Which of the following complications is less likely to occur in type II diabetics, as opposed to type I diabetics?
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16-A young man with normocytic anemia, jaundice, and splenomegaly was diagnosed as having RBC pyruvate kinase deficiency after a peripheral blood smear showed spiculated cells. Glucuronidation involves the addition of a glucose molecule that has been changed by which of the following processes to form glucuronic acid ? Journal of the European Academy of Dermatology and Venereology. Alpha Amylase is an enzyme for digestion of starch and glycogen.
28-A 30-month-old female child whose growth rate has been in the lower 10th percentile over the last year presents with chronic, nonproductive cough and diarrhea with foul-smelling stools. Lactate, the end product of glycolysis in erythrocytes and during intense exercise in skeletal muscles ,is mobilized through Cori cycle to liver to provide glucose by the process of gluconeogenesis. What biochemical activity might be deficient in the baby if her medication is continued as such? Cyanide inhibits the cytochrome oxidase of electron transport chain .
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A 3-month-old infant presents with hepatosplenomegaly and failure to thrive. Fatty acids due to long hydrophobic chain cannot cross blood brain barrier. A 16-year-old female presents with a fever, productive cough and rust colored sputum.
A breast-fed infant began to vomit frequently and lose weight. Thiamine is required as a coenzyme for Pyruvate dehydrogenase complex, alpha ketoglutarate dehydrogenase complex, transketolase and alpha keto acid dehydrogenase complex. Please help “Biochemistry for Medics” by CLICKING ON THE ADVERTISEMENTS above! Acute sirolimus pulmonary toxicity in an infant heart transplant recipient: case report and literature review”.
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Dopamine is used for raising the blood pressure in patients of shock. 27-What would be the consequences of a deficiency of vitamin B12 on fatty acid oxidation? Hence protein breakdown contributes only a little towards formation of Acetyl co A. Lactose intolerance is caused by a deficiency of the enzyme lactase, which is produced by the cells lining the small intestine. During an extended period of exercise, the enzymes involved in the glycolytic pathway in muscle tissue are actively breaking down glucose to provide the muscle energy.
Nitric oxide was previously referred as endothelial derived relaxing factor. The safety and efficacy of sirolimus treatment of LAM were investigated in clinical trials that compared sirolimus treatment with a placebo group in 89 patients for 12 months. A comprehensive review of immunosuppression used for liver transplantation”. Prostaglandins are synthesized from which of the following? Piperine was discovered in 1819 by Hans Christian Ørsted, who isolated it from the fruits of Piper nigrum, the source plant of both black and white pepper. Excess fructose is converted to glycogen that can be stored in liver.
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This page was last edited on 3 April 2018, at 16:52. His brain has reduced its need for glucose by using which of the following substances as an alternate source of energy? The affected patients present with Methylmalonic aciduria. Although the body’s ability to produce lactase cannot be changed, the symptoms of lactose intolerance can be managed with dietary changes. Heme is synthesized in living cells by a pathway that requires Succinyl-CoA, derived from the citric acid cycle in mitochondria, and the amino acid glycine. I have a fifty year history of UTIs and am always on antibiotics.
Neural cells convert tyrosine to epinephrine and norepinephrine. It is absent in adipose tissue, that is the reason glycerol released by hydrolysis of triglycerides cannot be reutilized there . A decrease in both Km and Vmax is observed in uncompetitive inhibition. Both components are present on the same polypeptide chain.
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Effect of Coleus forskohlii extract on cafeteria diet-induced obesity in rats. Laboratory examination reveals ketones in her urine. Thus the right answer is pancreatic lipase. In the production of urea, which of the following is an important intermediate? The GGT is shown to be dramatically elevated.
Urea formation requires the participation of 6 amino acids which are aspartic acid, ornithine, citrulline, argino succinic acid, arginine and N-Acetyl glutamate. Which of the following enzymes is not present in adipose tissue? As VLDLs pass through the circulation triacylglycerols are degraded by lipoprotein lipase, causing VLDLs to shrink in size and become denser. Weight gain can occur in both types, it is the result of treatment with insulin or certain hypoglycemic drugs.
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Estrogens block the action of thyroid hormones, so the dose of thyroid hormone must be increased. Insulin and C-peptide are synthesized in the equimolar concentrations. After multiple tests, he is diagnosed with Zellweger syndrome, a disorder caused by malformation of peroxisomes. Cholesterol is the final product of the pathway. Drug Discovery: Practices, Processes, and Perspectives. Triglycerides stores in adipose tissue are decreased due to adipolysis under the influence of glucagon.
30- Which of the following tissues can metabolize glucose, fatty acids, and ketone bodies for ATP production? Dopa decarboxylase, a pyridoxal phosphate-dependent enzyme, forms dopamine. It cannot cause the symptoms of high blood triglyceride levels and Steatorrhea. His serum level of glucose and ketone are abnormally low.
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Fatty acids cannot cross the blood brain barrier due to the presence of a long hydrophobic chain thus brain cells cannot use fatty acids as a source of energy. She gets lost and stays without water and food for 5 days. There is inhibition of TCA cycle affecting brain, causing neurological manifestations and death. Amino acids cannot be directly utilized, the carbon skeleton is oxidized in TCA cycle to provide energy or is used for glucose production. 45-A 6-month-old infant is seen in the emergency room with a fractured rib and subdural hematoma.
This is determined by taking a blood sample before the next dose, which gives the trough level. She is pregnant and considering the risk of potential bleeding episodes in the infant, her physician is considering to change her medicine. The enhanced uptake of maternal oxygen by fetal Hb is due to less binding of 2, 3 BPG with fetal Hb. T cell responses for tumor immunity”.
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Glutamate is a precursor of GABA, glutamine, glucogenic, a neurotransmitter and is incorporated in to tissue proteins. Iron to prevent anemia and folic acid to prevent neural tube defects in the developing fetus. Super oxide dismutase is also a copper dependent natural antioxidant enzyme.
The electron transport chain contains three proton pumps linked by two mobile electron carriers. The above said patient is a known alcoholic, mal nourished and has heart failure . She is also tested for C-peptide, which is much higher than normal. It is not observed in Type 2 diabetes.
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Had it been a competitive inhibitor, km value would have increased, Vmax would have remained the same. Out of all the given options only alpha ketoglutarate dehydrogenase is the only enzyme which is Thiamine dependent and that could possibly be inhibited in beri-beri. Treatment with thiamine did not alleviate the lactic acidosis. Isopentenyl pyrophosphate is formed from Mevalonate. The patient is most probably suffering from cardiac beriberi.
The girl is 5 ft tall and weighs 80 lb. Which of the following would be most likely to inhibit Isocitrate dehydrogenase? S-S- bonds in cystine units, reducing them to -SH groups.