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Buying drugs in your country requires a prescription. Take a multivitamin at least 2 hours before or after you take XENICAL, such as at bedtime.
Antiepileptic Drugs Convulsions have been reported in patients treated concomitantly with orlistat and antiepileptic drugs. If you take a levothyroxine medicine, take XENICAL and levothyroxine at least 4 hours apart.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. In several studies of up to 6-weeks duration, the effects of therapeutic doses of XENICAL on gastrointestinal and systemic physiological processes were assessed in normal weight and obese subjects. 0 out of 5 stars – Alli orlistat 60 mg – 120 Capsules – Weight Loss Aid. For example, a person who weighs 180 lbs and is 5’5″ has a BMI of 30.
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Cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure have been reported. The effect of XENICAL to delay the onset of type 2 diabetes in obese patients with IGT is presumably due to weight loss, and not to any independent effects of the drug on glucose or insulin metabolism. XENICAL is available for oral administration as a turquoise hard-gelatin capsule.
0 out of 5 stars – Alli orlistat 60 mg – 120 Capsules – Weight Loss Aid. Take XENICAL exactly as your doctor tells you to take it. Alli orlistat 60 mg – 120 Capsules – Weight Loss Aid. Discontinuation Of Treatment In controlled clinical trials, 8. Patients should also be advised to take multivitamin supplementation at least two hours before or after the administration of XENICAL, or at bedtime . Doses above 120 mg three times a day have not been shown to provide additional benefit.
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Buying drugs in your country requires a prescription. The relative changes in risk factors associated with obesity following 1 year of therapy with XENICAL and placebo are presented for the population as a whole and for the population with abnormal values at randomization. Fat-soluble Vitamin Supplements And Analogues Data from a pharmacokinetic interaction study showed that the absorption of beta-carotene supplement is reduced when concomitantly administered with XENICAL. HOW SUPPLIED Dosage Forms And Strengths XENICAL 120 mg turquoise capsules imprinted with ROCHE and XENICAL 120 in black ink.
Amiodarone A pharmacokinetic study, where amiodarone was orally administered during orlistat treatment, demonstrated a reduction in exposure to amiodarone and its metabolite, desethylamiodarone . Keep XENICAL and all medicines out of the reach of children. It is not known if XENICAL passes into your breast milk.
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For patients receiving both XENICAL and levothyroxine therapy, administer levothyroxine and XENICAL at least 4 hours apart. XENICAL and other medicines may affect each other causing side effects. Do not give XENICAL to other people, even if they have the same symptoms that you have.
Orlistat is a white to off-white crystalline powder. Each capsule contains a pellet formulation consisting of 120 mg of the active ingredient, orlistat, as well as the inactive ingredients microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, and talc. The diet prescribed in the second year was designed to maintain patient’s current weight. Take XENICAL with your meals or up to one hour after your meal. Cholelithiasis Substantial weight loss can increase the risk of cholelithiasis.
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For patients receiving both XENICAL and cyclosporine therapy, administer cyclosporine 3 hours after XENICAL. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. XENICAL 120 mg Capsules: Turquoise, two-piece, No.
If a meal is occasionally missed or contains no fat, the dose of XENICAL can be omitted. Talk to your doctor before you breastfeed and take XENICAL. Pediatric Use Safety and effectiveness in pediatric patients below the age of 12 have not been established. For XENICAL, the most common adverse events resulting in discontinuation of treatment were gastrointestinal.
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Table 4 illustrates the percentage of adult patients on XENICAL and placebo who developed a low vitamin level on two or more consecutive visits during 1 and 2 years of therapy in studies in which patients were not previously receiving vitamin supplementation. XENICAL inhibited absorption of a vitamin E acetate supplement. All studies, with the exception of 14 161, were conducted at centers specializing in treating obesity or complications of obesity.
Caution should be exercised when XENICAL is administered to a nursing woman. Clinical Studies The long-term effects of XENICAL on morbidity and mortality associated with obesity have not been established. XENICAL may affect the way other medicines work, and other medicines may affect the way XENICAL works. DRUG INTERACTIONS Cyclosporine Data from a XENICAL and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when XENICAL was coadministered with cyclosporine. The relative changes in risk factors associated with obesity following 2 years of therapy were also assessed in the population as a whole and the population with abnormal risk factors at randomization.
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Keep XENICAL in a tightly closed container. The safety and efficacy of XENICAL have been evaluated in obese adolescent patients aged 12 to 16 years. Digoxin In 12 normal-weight subjects receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not alter the pharmacokinetics of a single dose of digoxin. Your doctor will tell you how much XENICAL to take and when to take it. 0 out of 5 stars – Alli Orlistat 60 mg Weight Loss Aid 120 Capsules. SIDE EFFECTS Clinical Trials Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in patients.
These are not all the possible side effects of XENICAL. To reduce the chance of a drug-drug interaction, cyclosporine should be taken at least 3 hours before or after XENICAL in patients taking both drugs. 24 hours in XENICAL and placebo treatment groups, respectively. Pediatric Patients In clinical trials with XENICAL in adolescent patients ages 12 to 16 years, the profile of adverse reactions was generally similar to that observed in adults.
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0 out of 5 stars – Alli Orlistat 60 mg Weight Loss Aid 120 Capsules. One-year Results : Weight Loss, Weight Maintenance, And Risk Factors Pooled data from five clinical trials indicated that the overall mean weight loss from randomization to the end of 1 year of treatment in the intent-to-treat population was 13. They may not work as well while you take XENICAL.
There have been reports of hepatic failure observed with the use of XENICAL in postmarketing surveillance, with some of these cases resulting in liver transplant or death . Use In Specific Populations Pregnancy Pregnancy Category X XENICAL is contraindicated during pregnancy, because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. XENICAL is a prescription medicine used with a low calorie diet to increase weight loss in people with obesity. The iron balance was decreased by 64.
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Safely throw away medicine that is out of date or no longer needed. Alli orlistat 60 mg – 120 Capsules – Weight Loss Aid. Do not use XENICAL for a condition for which it was not prescribed. Pharmacokinetics Absorption Systemic exposure to orlistat is minimal. Patients should be advised to adhere to dietary guidelines . In the 4-year XENDOS study, the general pattern of adverse events was similar to that reported for the 1- and 2-year studies with the total incidence of gastrointestinal-related adverse events occurring in year 1 decreasing each year over the 4-year period.
Ethanol does not affect orlistat’s effect on preventing the absorption of fat. The daily intake of fat, carbohydrate, and protein should be distributed over three main meals. Specific Populations No pharmacokinetic study was conducted for specific populations such as geriatric, different races, and patients with renal and hepatic impairment.
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XENICAL and placebo treatment groups, respectively. In addition, all patients were offered nutritional counseling. Oily discharge may be clear or have a coloration such as orange or brown. Patients treated concomitantly with XENICAL and levothyroxine should be monitored for changes in thyroid function.
All studies, with the exception of 14 161, were conducted at centers specialized in treating obesity and complications of obesity. Trending price is based on prices over last 90 days. It is a single diastereomeric molecule that contains four chiral centers, with a negative optical rotation in ethanol at 529 nm. Four-year Results : Long-term Weight Control And Risk Factors In the 4-year double-blind, placebo-controlled XENDOS study, the effects of XENICAL in delaying the onset of type 2 diabetes and on body weight were compared to placebo in 3304 obese patients who had either normal or impaired glucose tolerance at baseline. Clinical signs include palpable purpura, maculopapular lesions, or bullous eruption.