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This means you will usually take one capsule at breakfast time, one capsule at lunch time and one capsule at dinner time. The majority of orlistat overdose cases received during post- marketing reported either no adverse events or adverse events that are similar to those reported with recommended dose. Based on animal data, it is likely that the metabolism of orlistat occurs mainly within the gastrointestinal wall.
Studies in normal weight and obese volunteers have shown that the extent of absorption of orlistat was minimal. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Increase in liver transaminases and in alkaline phosphatase. Stop Orlistat if such symptoms occur and tell your doctor. Each hard capsule contains 120 mg orlistat.
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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease. The usual dose of Orlistat is one 120 mg capsule taken with each of the three main meals per day. It is written for patients and gives information about taking or using a medicine.
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is recommended that the diet should be rich in fruit and vegetables. In addition, doses of 240 mg tid have been administered to obese patients for 6 months. Buying drugs in your country requires a prescription.
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Find out everything you need to know about weight loss drugs in our prescription weight loss pill guide. In a 4 year clinical trial, the general pattern of adverse event distribution was similar to that reported for the 1 and 2 year studies with the total incidence of gastrointestinal related adverse events occurring in year 1 decreasing year on year over the four year period. Orlistat is a potent, specific and long-acting inhibitor of gastrointestinal lipases. You may need to read it again.
You can also report side effects directly via the MHRA Yellow Card Scheme — Website: www. The vast majority of patients receiving up to four full years of treatment with orlistat in clinical studies had vitamin A, D, E and K and beta-carotene levels that stayed within normal range. This information has been compiled for use by healthcare practitioners and consumers in the United States. The capsule should be swallowed with water. Some fatal cases or cases requiring liver transplantation have been reported.
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Co-administration with ciclosporin is not recommended. Not all pack sizes may be marketed. 6 kg between the two groups.
06 kg and the mean difference from placebo in HbA1c reduction was 0. Taking Orlistat during pregnancy is not recommended. Orlistat is a medicine used to treat obesity. Buying drugs in your country requires a prescription.
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The expiry date refers to the last day of that month. Buying drugs in your country requires a prescription. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Contact your doctor immediately if you experience any of these. It may harm them, even if their signs of illness are the same as yours. Your daily intake of fat, carbohydrate and protein should be distributed over three meals.
Store in the original package in order to protect from light and moisture. This medicine can cause harmless changes in your bowel habits, such as fatty or oily stools, due to the elimination of undigested fat in your faeces. Orlistat is not intended to be used in children. You may ask your doctor for advice. Do not pass it on to others.
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Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction. For further information call RNIB Medicine Leaflet Line on 0800 198 5000. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Orlistat has no known effect on your ability to drive a car or operate machinery. Antidiabetic medicinal product treatment may have to be closely monitored when taking orlistat. Orlistat is indicated in the treatment of obesity in conjunction with a low calorie intake diet. Your doctor may need to monitor your blood coagulation. Based on human and animal studies, any systemic effects attributable to the lipase-inhibiting properties of orlistat should be rapidly reversible.
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A decrease in ciclosporin plasma levels has been observed in a drug-drug-interaction study and also reported in several cases, when orlistat was administered concomitantly. In the 2-year studies and the 4-year study, a hypocaloric diet was used in association with treatment in both the orlistat and the placebo treated groups. Do not pass it on to others. Orlistat has been studied in long-term clinical studies of up to 4 years duration. Orlistat capsules are hard gelatin, blue capsules: content is white powder or slightly compacted agglomerates: size of capsules No.
The reason for this difference is that the five 2-year studies included a 4-week diet and placebo lead-in period during which patients lost on average 2. To email a medicine you must be a registered user. In animal reproductive studies, no teratogenic effect was observed. The text only version may be available from RNIB in large print, Braille or audio CD. This medicine has been prescribed for you only.
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If you take more capsules than you have been told to take, or if someone else accidentally takes your medicine, contact a doctor, pharmacist or hospital as you may need medical attention. Orlistat is not intended to be used in children. Buying drugs in your country requires a prescription. These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat. To bookmark a medicine you must be a registered user.
You may ask your doctor for advice. This is important as using more than one medicine at the same time can strengthen or weaken the effects of the medicines. In the absence of a teratogenic effect in animals, no malformative effect is expected in man. As it is not known whether orlistat is secreted into human milk, orlistat is contra- indicated during breast-feeding. The mean difference in weight loss with the drug compared to placebo was 3.
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Doses of orlistat above 120 mg three times daily have not been shown to provide additional benefit. If you have further questions on the use of this medicine, ask your doctor or pharmacist. As with any weight-control program, over-consumption of fat and calories may reduce any weight loss effect.
Store in the original package in order to protect from light and moisture. In patients receiving concomitant amiodarone treatment, reinforcement of clinical and ECG monitoring is warranted. Do not take a double dose. The possibility of this happening may increase if Orlistat is taken with a diet high in fat. The effect of orlistat results in an increase in faecal fat as early as 24 to 48 hours after dosing. Not all pack sizes may be marketed.
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By reporting side effects you can help provide more information on the safety of this medicine. Hypersensitivity to the active substance or to any of the excipients. Cases of rectal bleeding have been reported with orlistat. Buying drugs in your country requires a prescription. You should therefore follow your doctor’s advice in taking a well balanced diet rich in fruit and vegetables.
However, orlistat may indirectly reduce the availability of oral contraceptives and lead to unexpected pregnancies in some individual cases. Below is a text only representation of the Patient Information Leaflet, the original can be viewed in PDF format using the link above. Like all medicines, this medicine can cause side effects, although not everybody gets them. Always take Orlistat exactly as your doctor has told you. For the full list of excipients, see section 6.