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WARNINGS Included as part of the PRECAUTIONS section. Alli Orlistat 60 mg Weight Loss Aid 120 Capsules. XENICAL and cyclosporine should not be simultaneously coadministered.
Buying drugs in your country requires a prescription. If you forget to take your medicine at any time, take it as soon as you remember provided this is within one hour of your last meal, then continue to take it at the usual times. Before taking your medicine please read the patient information leaflet in detail to acquaint yourself with the potential side effects.
120mg Capsules – Like all medicines, Xenical can cause side effects, although not everybody gets them. Study 14 161 was conducted with primary care physicians. Elimination Following a single oral dose of 360 mg 14C-orlistat in both normal weight and obese subjects, fecal excretion of the unabsorbed drug was found to be the major route of elimination.
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Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Because the fat cannot be digested it is eliminated from the body. Patients should also be advised to take multivitamin supplementation at least two hours before or after the administration of XENICAL, or at bedtime . Pravastatin In a 2-way crossover study of 24 normal-weight, mildly hypercholesterolemic patients receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not affect the pharmacokinetics of pravastatin. Cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure have been reported. Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.
Cases of rectal bleeding have been reported with orlistat. You can report adverse effects directly. Rare cases of leukocytoclastic vasculitis have been reported. In the absence of pharmacokinetic interaction studies, the concomitant administration of orlistat with acarbose should be avoided. To reduce the chance of a drug-drug interaction, cyclosporine should be taken at least 3 hours before or after XENICAL in patients taking both drugs.
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In patients found to have an impaired OGTT at randomization, the percent of patients improving to normal or deteriorating to diabetic status following 1 and 2 years of treatment with XENICAL compared to placebo are presented. This information does not take the place of talking to your doctor about your medical condition or your treatment. They work in your digestive system and block about a third of the food in the fat you eat from being digested. The main rule of thumb is, dont let anything pass your lips that has more than 5g of fat per 100g and you cant go far wrong. In one-year clinical trials, between 35. This study showed no evidence of an increased risk of liver injury during treatment.
XENICAL-treated patients and increased by an average of 0. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Based on human and animal studies, any systemic effects attributable to the lipase-inhibiting properties of orlistat should be rapidly reversible. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
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Postmarketing Experience The following adverse reactions have been identified during postapproval use of XENICAL. Studies in normal weight and obese volunteers have shown that the extent of absorption of orlistat was minimal. Orlistat is a medicine used to treat obesity. GI adverse events associated with XENICAL treatment lasted for less than 1 week, and a majority lasted for no more than 4 weeks. As it is not known whether orlistat is secreted into human milk, orlistat is contra- indicated during breast-feeding. It can be taken immediately before, during or up to 1 hour after eating a meal and swallowed with water.
Adverse reactions to orlistat are largely gastrointestinal in nature. In the 4-year XENDOS study, the general pattern of adverse events was similar to that reported for the 1- and 2-year studies with the total incidence of gastrointestinal-related adverse events occurring in year 1 decreasing each year over the 4-year period. Your doctor may need to monitor your ciclosporin blood levels more frequently than usual.
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Your GP can assess whether your current weight is healthy by measuring your Body Mass Index. Medisellers is operating as an exporter, supplier, wholesaler and trader of a wide gamut of Anti Cancer Medicines. Always read the patient information leaflet before commencing treatment. XENICAL patients had a normal oral glucose tolerance test while 10.
Table 5 illustrates the percentage of adolescent patients on XENICAL and placebo who developed a low vitamin level on two or more consecutive visits during the 1-year study. HOW SUPPLIED Dosage Forms And Strengths XENICAL 120 mg turquoise capsules imprinted with ROCHE and XENICAL 120 in black ink. Nursing Mothers It is not known if XENICAL is present in human milk. Caution should be exercised when XENICAL is administered to a nursing woman.
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Buying drugs in your country requires a prescription. Digoxin In 12 normal-weight subjects receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not alter the pharmacokinetics of a single dose of digoxin. In addition, all patients were placed on a behavior modification program and offered exercise counseling. Simply add to basket and head to the checkout to begin your consultation. Below is a text only representation of the Patient Information Leaflet, the original can be viewed in PDF format using the link above. Based on animal data, it is likely that the metabolism of orlistat occurs mainly within the gastrointestinal wall.
However, GI adverse events may occur in some individuals over a period of 6 months or longer. Based on fecal fat measurements, the effect of XENICAL is seen as soon as 24 to 48 hours after dosing. Based on patients with a baseline and at least one follow-up OGTT measurement, ITT LOCF study population. The recommended dose of orlistat is one 120 mg capsule taken with water immediately before, during or up to one hour after each main meal. The incidence of adverse events decreased with prolonged use of orlistat. Not all pack sizes may be marketed.
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Talk to your doctor before you breastfeed and take XENICAL. Take a multivitamin at least 2 hours before or after you take XENICAL, such as at bedtime. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet. Clinical Studies The long-term effects of XENICAL on morbidity and mortality associated with obesity have not been established. If you have any questions or concerns, please speak to your GP in the first instance. In patients receiving amiodarone treatment, the clinical relevance of this effect remains unknown but may become clinically relevant in some cases.
Trending price is based on prices over last 90 days. The inactivated enzyme is thus unavailable to hydrolyse dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides. Lowered absorption of certain vitamins in your body. However, orlistat may indirectly reduce the availability of oral contraceptives and lead to unexpected pregnancies in some individual cases. The absence of an interaction between oral contraceptives and orlistat has been demonstrated in specific drug-drug interaction studies.
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Certificate Extending Patent Term Under 35 U. Rare cases of hypersensitivity have been reported with the use of XENICAL. Single doses of 800 mg orlistat and multiple doses of up to 400 mg three times daily for 15 days have been studied in normal weight and obese subjects without significant adverse findings.
Call your doctor for medical advice about side effects. The capsule should be swallowed with water. Drug information contained herein may be time sensitive. Xenical Patient Information is supplied by Cerner Multum, Inc.
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Orlistat is a potent, specific and long-acting inhibitor of gastrointestinal lipases. Therefore, XENICAL and cyclosporine should not be simultaneously coadministered. Orlistat is indicated in the treatment of obesity in conjunction with a low calorie intake diet. The volume of distribution cannot be determined because the drug is minimally absorbed and has no defined systemic pharmacokinetics.
However, GI adverse events may occur in some individuals over a period of 6 months or longer. Checkout and pay If you’re done shopping, proceed to the checkout and pay for your order. Neither study showed embryotoxicity or teratogenicity.
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Xenical attaches to the enzymes in your digestive system, known as lipases which are blocked from breaking down some of the fat you have eaten during your meal. At the end of year 1, the patients’ diets were reviewed and changed where necessary. Archived from the original on 29 December 2007. To bookmark a medicine you must be a registered user. Orlistat is the only proven weight loss treatment, licensed in the EU.
To email a medicine you must be a registered user. Table 5 illustrates the percentage of adolescent patients on XENICAL and placebo who developed a low vitamin level on two or more consecutive visits during the 1-year study. Alli Orlistat Weight Loss 120 ct Capsules. Weight-Loss Drug to Be Sold Over the Counter”. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to XENICAL exposure. Discontinuation Of Treatment In controlled clinical trials, 8.