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Geriatric Use Clinical studies of XENICAL did not include sufficient numbers of patients aged 65 years and older to determine whether they respond differently from younger patients . XENICAL-treated patients and increased by an average of 0.
Our clinical information is certified to meet NHS England’s Information Standard. Patients should not take XENICAL if they are pregnant, have chronic malabsorption syndrome, cholestasis or hypersensitivity to XENICAL or to any component of this product . If you are pregnant, trying for a baby or breast-feeding.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Do not take more than three doses a day. The iron balance was decreased by 64. Specific Populations No pharmacokinetic study was conducted for specific populations such as geriatric, different races, and patients with renal and hepatic impairment.
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You may report side effects to FDA at 1-800-FDA-1088. Do not give alli to anyone under 18 years old. Other drugs may interact with orlistat, including prescription and over-the-counter medicines, vitamins, and herbal products. Do not use in larger or smaller amounts or for longer than recommended.
For patients receiving both XENICAL and levothyroxine therapy, administer levothyroxine and XENICAL at least 4 hours apart. The lower-strength capsule is available from pharmacies whilst the higher-strength capsule is only available on a prescription from a doctor. Take the missed dose as soon as you remember, but no more than 1 hour after eating a meal. Pediatric Patients In clinical trials with XENICAL in adolescent patients ages 12 to 16 years, the profile of adverse reactions was generally similar to that observed in adults. Pravastatin In a 2-way crossover study of 24 normal-weight, mildly hypercholesterolemic patients receiving XENICAL 120 mg three times a day for 6 days, XENICAL did not affect the pharmacokinetics of pravastatin. In addition, all patients were placed on a behavior modification program and offered exercise counseling.
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They may not work as well while you take XENICAL. Medically reviewed on August 12, 2017. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. High-fat meals taken in combination with orlistat can increase your risk of unpleasant side effects on your stomach or intestines. Rare cases of leukocytoclastic vasculitis have been reported.
Levothyroxine Hypothyroidism has been reported in patients treated concomitantly with XENICAL and levothyroxine postmarketing. No causal relationship or physiopathological mechanism between pancreatitis and obesity therapy has been definitively established. If a meal is occasionally missed or contains no fat, the dose of XENICAL can be omitted.
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Stop taking orlistat and tell your doctor right away if you become pregnant. Take a multivitamin containing vitamins A, D, E, K, and beta-carotene one time each day. Your practice nurse will be able to give you further help and advice about eating a healthy diet and taking suitable exercise. Orlistat is a medicine that can help you to lose weight if you are obese or overweight.
24,000 prescription drugs, over-the-counter medicines and natural products. Medically reviewed on August 12, 2017. XENICAL is available for oral administration as a turquoise hard-gelatin capsule.
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The daily intake of fat, carbohydrate, and protein should be distributed over three main meals. 4 hours before or 4 hours after you take orlistat. XENICAL may affect the way other medicines work, and other medicines may affect the way XENICAL works.
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Do not give alli to anyone under 18 years old. HDL ratio and isolated systolic blood pressure were less than that observed in the year one results. Potential Risks And Benefits Patients should be informed of potential risks which include lowered absorption of fat-soluble vitamins and potential liver injury, increases in urinary oxalate, and cholelithiasis . Pharmacokinetics Absorption Systemic exposure to orlistat is minimal.
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Keep XENICAL in a tightly closed container. For patients receiving both XENICAL and cyclosporine therapy, administer cyclosporine 3 hours after XENICAL. If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
The safety and efficacy of XENICAL have been evaluated in obese adolescent patients aged 12 to 16 years. Other drugs may interact with orlistat, including prescription and over-the-counter medicines, vitamins, and herbal products. You should not use Xenical if you have gallbladder problems, or if you are pregnant. It is not known if XENICAL is safe and effective in children under 12 years old. Xenical is the prescription-strength form of orlistat.
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Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Not all possible interactions are listed in this medication guide. 2, with black printing ink containing pharmaceutical grade shellac, propylene glycol, strong ammonium solution, potassium hydroxide and black iron oxide. In several studies of up to 6-weeks duration, the effects of therapeutic doses of XENICAL on gastrointestinal and systemic physiological processes were assessed in normal weight and obese subjects.
These enzymes normally break down the fat which you consume in your diet, allowing it to be absorbed into your bloodstream. For XENICAL, the most common adverse events resulting in discontinuation of treatment were gastrointestinal. If you take a levothyroxine medicine, take XENICAL and levothyroxine at least 4 hours apart. 4 hours before or 4 hours after you take Xenical. Avoid a diet that is high in fat.
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You may take the medicine either with your meal or up to 1 hour after eating. Should a significant overdose of XENICAL occur, it is recommended that the patient be observed for 24 hours. In addition, all patients were offered nutritional counseling. Avoid eating high-fat meals or you could have unpleasant side effects on your stomach or intestines. The number where these two meet is your BMI.
Table 4 illustrates the percentage of adult patients on XENICAL and placebo who developed a low vitamin level on two or more consecutive visits during 1 and 2 years of therapy in studies in which patients were not previously receiving vitamin supplementation. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. In general, the first occurrence of these events was within 3 months of starting therapy.
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BMI is calculated by dividing your weight in kilograms by the square of your height in metres. Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xenical only for the indication prescribed. Pediatric Use Safety and effectiveness in pediatric patients below the age of 12 have not been established. XENICAL and placebo treatment groups, respectively. Do not use Xenical if you are pregnant. Safely throw away medicine that is out of date or no longer needed.
Common Xenical side effects are caused by orlistat’s fat-blocking action. In patients found to have an impaired OGTT at randomization, the percent of patients improving to normal or deteriorating to diabetic status following 1 and 2 years of treatment with XENICAL compared to placebo are presented. The table below contains some of the most common ones associated with orlistat. Rare cases of hypersensitivity have been reported with the use of XENICAL. 7 2a1 1 0 0 1-. It prevents the action of enzymes found in the digestive juices of your stomach and small intestine.
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This is not a complete list of side effects and others may occur. The information on this page is written and peer reviewed by qualified clinicians. Taking orlistat can make it harder for your body to absorb certain vitamins. If you skip a meal or you eat a meal that does not contain any fat, skip your dose for that meal. Patient does not provide medical advice, diagnosis or treatment.
1 Oily discharge may be clear or have an orange or brown color. Do not use this medicine without a doctor’s advice if you are breast-feeding a baby. These symptoms generally occur at the start of treatment as your body is adjusting. Xenical is only part of a complete program of treatment that also includes diet, exercise, and weight control.